Jiaying Huang

GMU-GIBH Joint School of Life Sciences, GMU

 

Principal Investigator

 

Medical Genome Editing Lab   |   PI

 

Professor | Doctoral supervisor

| Introduction

Dr. Huang is a Professor in the GMU-GIBH Joint School of Life Sciences at Guangzhou Medical University. She received his B.S. degree in Life Science (Xiangqin Innovation Class) in 2015, supervised by Prof. Hongqing Li. She spent one and a half year at the Beijing Genomics Institute(BGI), Shenzhen as a visiting student during 2014 to 2015, supervised by Prof. Shifeng Cheng. In 2021, she obtained Ph.D. at School of Life Sciences, Peking University, supervised by Prof. Li-Jia Qu. During 2019-2020, she went to Rutgers University as a visiting student supported by China Scholarship Council (CSC), supervised by Prof. Juan Dong. During 2021 to 2023, she joined the team of Prof. Caixia Gao as a postdoctoral fellow. In 2023, she started her lab in Guangzhou Medical University. Huang interested in discovering genome editing tools, she developed novel base editing technologies for therapeutic and agricultural applications by AI-predicted structure-based protein clustering, which broke through the bottlenecks of current base editing tools.She has published first author papers in Cell, Current Opinion in Plant Biology, and Scientific Reports. She applied 2 PCT patents and grant 2 invention patents.


| Professional Career

  • 2023-Now Professor, GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University
  • 2021-2023 Postdoctoral Fellow, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

| Education history

  • 2019-2020 Visiting student (supported by China Scholarship Council (CSC)), Waksman Institute of Microbiology, Rutgers, The State University of New Jersey
  • 2015-2021 PhD in Biotechnology, School of Life Sciences, Peking University
  • 2014-2015 Visiting student, Beijing Genomics Institute, Shenzhen.
  • 2011-2015 B.Sc. in Life Science (Xiangqin Class), School of Life Sciences, South China Normal University

| Publications

    (1 co-first author;* corresponding author)

  • Huang, J.1, Lin, Q.1, Fei, H.1, He, Z.1, Xu, H., Li, Y., Qu, K., Han, P., Gao, Q., Li, B., Liu, G., Zhang, L., Hu, J., Zhang, R., Zuo, E., Luo, Y., Ran, Y., Qiu, J.L., Zhao, K.T.*, and Gao, C.* (2023). Discovery of deaminase functions by structure-based protein clustering. Cell. https://doi.org/10.1016/j.cell.2023.05.041.

  • Huang, J.1, Dong, J.*, & Qu, L.J.* (2021). From birth to function: Male gametophyte development in flowering plants. Curr. Opin. Plant Biol. 63, 102118.

  • Valliyodan, B.1, Qiu, D.1, Patil, G.1, Zeng, P.1, Huang, J.1, Dai, L.1, Chen, C., Li, Y., Joshi, T., Song, L., Vuong, T. D., Musket, T. A., Xu, D., Shannon, J. G., Shifeng, C., Liu, X., & Nguyen, H.T.* (2016). Landscape of genomic diversity and trait discovery in soybean. Sci. Rep. 6, 23598.

  • Shi, Y., Huang, J., Sun, T., Wang, X., Zhu, C., Ai, Y., and Gu, H.* (2017). The precise regulation of different COR genes by individual CBF transcription factors in Arabidopsis thaliana. J. Integr. Plant Biol. 59, 118-133.

  • Sun, Y., Huang, J., Zhong, S., Gu, H., He, S., and Qu, L.J.* (2018). Novel DYW-type pentatricopeptide repeat (PPR) protein BLX controls mitochondrial RNA editing and splicing essential for early seed development of Arabidopsis. J. Genet. Genomics 45, 155-168.

  • Iorizzo, M., Ellison, S., Senalik, D., Zeng, P., Satapoomin, P., Huang, J., Bowman, M., Iovene, M., Sanseverino, W., Cavagnaro, P., Yildiz, M., Macko-Podgórni, A., Moranska, E., Grzebelus, E., Grzebelus, D., Ashrafi, H., Zheng, Z., Cheng, S., Spooner, D., Van Deynze, A., and Simon, P. (2016). A high-quality carrot genome assembly provides new insights into carotenoid accumulation and asterid genome evolution. Nat. Genet. 48, 657-666.

  • Zhang, J.1, Huang, Q.1, Zhong, S.1, Bleckmann, A., Huang, J., Guo, X., Lin, Q., Gu, H., Dong, J., Dresselhaus, T., and Qu, L.J.* (2017). Sperm cells are passive cargo of the pollen tube in plant fertilization. Nat. Plants 3, 17079.

  • Zhong, S.1, Liu, M.1, Wang, Z.1, Huang, Q., Hou, S., Xu, Y. C., Ge, Z., Song, Z., Huang, J., Qiu, X., Shi, Y., Xiao, J., Liu, P., Guo, Y. L., Dong, J., Dresselhaus, T., Gu, H., and Qu, L.J.* (2019). Cysteine-rich peptides promote interspecific genetic isolation in Arabidopsis. Science 364, eaau9564.

  • Yuan, R., Lan, J., Fang, Y., Yu, H., Zhang, J., Huang, J., and Qin, G.* (2018). The Arabidopsis USL1 controls multiple aspects of development by affecting late endosome morphology. New Phytol. 219, 1388-1405.

  • Cheng, S.1, Gutmann, B.1, Zhong, X.1, Ye, Y., Fisher, M.F., Bai, F., Castleden, I., Song, Y., Song, B., Huang, J., Liu, X., Xu, X., Lim, B. L., Bond, C.S., Yiu, S.M., Small, I.* (2016). Redefining the structural motifs that determine RNA binding and RNA editing by pentatricopeptide repeat proteins in land plants. Plant J. 85, 532-547.